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ea0029p1374 | Pituitary Clinical | ICEECE2012

Circulating total and high molecular weight adiponectin levels are lower in adult GH deficient subjects

Caputo M. , Prodam F. , Garbaccio V. , Sama M. , Zavattaro M. , Pagano L. , Marzullo P. , Aimaretti G.

Introduction: Regulation of adiponectin in GH deficiency (GHD), which presents visceral obesity, is still a matter of debate. No studies have evaluated circulating adiponectin isoforms in adult GHD subjects. Aim of this study was to evaluate total adiponectin (TA) and its isoforms (high molecular weight: HMW, medium molecular weight: MMW, low molecular weight: LMW) in hypopituitary adult subjects with and without GHD, in relation to weight, IGF1 and GH levels.<p class="abs...

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ea0029p700 | Diabetes | ICEECE2012

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

Dicembrini I. , Di Pasquale G. , Raimondi L. , Pagano C. , Egan J. , Cozzi A. , Cinci L. , Manni E. , Loreto A. , Berretti S. , Morelli A. , Baum B. , Maggi M. , Vettor R. , Chiorini J. , Rotella C. , Mannucci E.

Background: Exendin-4 (Ex-4) is a GLP-1 receptor agonist approved for the treatment of Type 2 Diabetes (T2DM). Aim of this study was to characterize the effects of Ex-4 expressed continuously from salivary glands (SG), following adeno-associated virus-mediated (AAV) gene therapy in two different model of obesity and T2DM. Several trials support an AAV good safety and little toxicity profile. Serotype 5 (AAV5) presented enhanced gene transfer activity in SG and an efficient pro...

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Endocrine Abstracts

Circulating total and high molecular weight adiponectin levels are lower in adult GH deficient subjects

Sustained Exendin-4 secretion through gene therapy targeting salivary glands in Zucker fa/fa rats and high fat diet fed mice.

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